Geomorphology of the Kaikoura area

The major physiographic units in the Kaikoura area are the Peninsula Block, Beach Ridges and Raised Beaches, Hard Rock Areas and the Alluvial Fans. Erosion of the Seaward Kaikoura Mountains and the transfer of the debris to the sea by fan streams have contributed to coastline pro gradation so that a former offshore island, now called the Kaikoura Peninsula, has been joined to the mainland. On the piedmont alluvial plain between the mountains and the sea Otiran Glacial Stage and Holocene fan deposits have covered up older fan surfaces. Stillstands during the tectonic uplift of the Peninsula Block when marine processes cut shore platforms and also higher stands of interglacial sea levels in the Late Pleistocene have contributed to the development of erosion surfaces. Along the coast beach ridges and raised beaches have developed during post-glacial times

The steady state stability of synchronous machine as affected by direct and quadrature axis excitation regulators

Imperial Users onl

Parallel Suffix Tree Construction for Genome Sequence Using Hadoop

Indexing the genome is the basis for many of the bioinformatics applications. Read mapping (sequence alignment) is one such application to align millions of short reads against reference genome. Several tools like BLAST, SOAP, BOWTIE, Cloudburst, and Rapid Parallel Genome Indexing with MapReduce use indexing technique for aligning short reads. Many of the contemporary alignment techniques are time consuming, memory intensive and cannot be easily scaled to larger genomes. Suffix tree is a popular data structure which can be used to overcome the demerits of other alignment techniques. However, constructing the suffix tree is highly memory intensive and time consuming. In this thesis, a MapReduce based parallel construction of the suffix tree is proposed. The performance of the algorithm is measured on the hadoop framework over commodity cluster with each node having 8GB of primary memory. The results show a significantly less time for constructing suffix tree for a big data like human genome

Code Prediction by Feeding Trees to Transformers

We advance the state-of-the-art in the accuracy of code prediction (next token prediction) used in autocomplete systems. First, we report that using the recently proposed Transformer architecture even out-of-the-box outperforms previous neural and non-neural systems for code prediction. We then show that by making the Transformer architecture aware of the syntactic structure of code, we further increase the margin by which a Transformer-based system outperforms previous systems. With this, it outperforms the accuracy of an RNN-based system (similar to Hellendoorn et al. 2018) by 18.3\%, the Deep3 system (Raychev et al 2016) by 14.1\%, and an adaptation of Code2Seq (Alon et al., 2018) for code prediction by 14.4\%. We present in the paper several ways of communicating the code structure to the Transformer, which is fundamentally built for processing sequence data. We provide a comprehensive experimental evaluation of our proposal, along with alternative design choices, on a standard Python dataset, as well as on a Facebook internal Python corpus. Our code and data preparation pipeline will be available in open source

Study of analeptics

The improvement of lowered conditions of vitality brought on by disease or poisoning must have been a problem engaging the serious attention of people practising the healing art from the earliest days of human civilisation. This led to the use of various agencies, supposed to possess reviving powers, some of which survived through long periods of usage. Therapeutics in early days was purely empirical. Even after considerable advances in the knowledge of the pathology of these lowered conditions of vitality, very little attention was paid to enquiring into the nature of the reviving power of these agencies(by which was perhaps meant the improvement of some symptoms of lowered conditions). In many cases the improvement was due to the strong local irritant action of alcohol and other irritant constituents of the medicaments on the gastric mucosa, setting up a strong reflex stimulation of the respiratory and vasomotor centres and also perhaps partly to alcoholic contents thereof, acting as a diffusible stimulant, and supplying ready nutrition to tissues. A few did act after absorption, and some of these caused improvements in lowered conditions by improving the circulation as cardio -vascular stimulants and a few others really acted through the nervous system, especially through the respiratory and other vital centres.Development of modern surgery brought in its train the use of anaesthetics which have their risks of extreme depression. This inspired an increased study of the nature of reviving drugs. With the rapid increase in the use of barbiturates as basal narcotics and anaesthetics, and also with the occurrence of poisoning, following their therapeutic administration, self- medication or suicidal attempts, the study of analeptic drugs has, in recent years, been engaging a good deal of attention of pharmacologists. Of the older drugs, picrotoxin and strychnine have been very thoroughly investigated, as also coramine and cardiazol amongst the newer synthetic drugs. Caffeine, cocaine, ephedrine, lobeline and a few others have also received some attention.The clinical use of some of these still persists in spite of their questionable status as judged by experimental evidences.No doubt a good number of therapeutic agents are of more or less symptomatic value in combating some of the effects of hypnotics and narcotics. But there is still a good deal of lack of unanimity regarding their usefulness in different stages of depression produced by the narcotics. The importance of the subject therefore called for further study of the analeptics.Moreover, methods employed for the study of the problem were diverse in nature, and most of them had some unsatisfactory feature or other. For a truer evaluation and determination of the comparative worth of these drugs it was found necessary to evolve an efficient method free from those unsatisfactory features. Investigations undertaken for these purposes form the subject of this thesis.Appendix - Two reprints from Quart. J. exper.Physiol. (a) Antagonism of evipan by picrotoxin, coramine and cardiazol. 1939 . 29, 355. || (b) (with J. Raventos). The Clearance of sodium evipan. 1939. 29, 343

Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery.

Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions. We investigated the unknown effects of extracellular acidosis on relaxation in the superior mesenteric artery (SMA) of goat. SMA rings were employed to maintain isometric contractions at extracellular pH (p